![]() Does pituitary compression/empty sella syndrome contribute to MRI-negative Cushing's disease? A single-institution experience. Himes BT, Bhargav AG, Brown DA, Kaufmann TJ, Bancos I, Van Gompel JJ. Association of MRI findings and visual outcome in idiopathic intracranial hypertension. Saindane AM, Bruce BB, Riggeal BD, Newman NJ, Biousse V. Factors determining the clinical significance of an "empty" sella turcica. Saindane AM, Lim PP, Aiken A, Chen Z, Hudgins PA. (2000) Journal of magnetic resonance imaging : JMRI. MR imaging of pituitary morphology in idiopathic intracranial hypertension. Yuh WT, Zhu M, Taoka T, Quets JP, Maley JE, Muhonen MG, Schuster ME, Kardon RH. Higher pituitary grades have been implicated in empty sella syndromes characterized by pituitary dysfunction, such as Cushing syndrome, without a mass identified on MRI 4. Among patients with idiopathic intracranial hypertension, higher pituitary grade is associated with higher likelihood of having a cephalocele, suggesting a common mechanism 3. Pituitary height loss grade shows age-related increases in patients with idiopathic intracranial hypertension but not incidental partially empty sella 2. In the original study, at least moderate concavity (category III) pituitary morphology had a sensitivity of 80% and specificity of 92% for the diagnosis of idiopathic intracranial hypertension compared to patients who are normal or have acutely increased intracranial pressure 1. V: no pituitary parenchyma observed and enlarged sella turcica (total empty sella).II: mild loss of pituitary height (h ⅔ H).This study evaluated which clinical and MRI findings could be used to differentiate patients with chronically elevated ICP from those with incidental empty sella turcica. It is particularly common in the setting of idiopathic intracranial hypertension (IIH). I: normal appearance (superior aspect of the gland is convex or flat) Although often incidental, the empty sella turcica can reflect chronically elevated intracranial pressure (ICP).1, the loss of pituitary height (h) and the sellar height (H) are measured on a midsagittal T1-weighted image and described in the following "categories" (grades): As a result of the weakened membrane, this fluid can leak into the sella turcica and apply pressure on the gland. Cerebrospinal fluid is the fluid that flows around the brain. GradingĪs originally described by Yuh et al. Primary Empty Sella Syndrome occurs in people who have a weakness in the membrane (diaphragma sellae) that normally covers the pituitary gland. Hormonal disturbances, psychiatric disorders, raised ICT and SNHL have been found to be more often associated with ES as compared to general population.Pituitary height grading describes degrees of loss of the pituitary height (concavity), which encompasses gradations of (partially) empty sella. The proportion of patients in the ES and non-empty sella groups for each of the variables were as follows: hormonal disturbances (3.31% vs 0.56%, P =. Association of ES and the select variables was analyzed by determining means and proportions and using Chi-square test.ĭuring the study period, a total of 12,414 patients underwent MRI brain studies at our centre. hormonal disturbances, headache, sensorineural hearing loss, seizures, vertigo, psychiatric disorders, visual disturbances, ataxia and raised intracranial tension, was analyzed amongst the study group, as well as the baseline population. To detect the prevalence of empty sella in routine MRI brain study and to find associations with other diseases.Ī retrospective study was carried out for patients undergoing MRI brain studies in the radiology department of a teaching institution. Recently, there have been studies documenting association of ES with hormonal and non-hormonal abnormalities. Empty sella (ES) has been regarded as an incidental finding. ![]()
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